© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature. Chronic, systemic inflammation is implicated in physical and mental health; little is known about whether sex and racial differences detected in adulthood are observed during adolescence or about normative changes occurring during adolescence. This longitudinal, United States-based study examined four biomarkers of systemic inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-8) in 315 adolescents (51% female; 58% black; baseline age = 16.49 years (SD = 1.56; range: 12.14–21.28)] at three timepoints. Notable results included: general decline in inflammatory biomarkers in older adolescents, lower levels of TNF-α/IL-8 in black adolescents, elevated CRP/IL-6 in females, and especially higher levels of IL-6 in black, female adolescents. Implications are discussed, particularly the potential health implications of elevated IL-6 in black females.
CITATION STYLE
Kaslow, N. J., Adamson, L. B., & Collins, M. H. (2000). A Developmental Psychopathology Perspective on the Cognitive Components of Child and Adolescent Depression. In Handbook of Developmental Psychopathology (pp. 491–510). Springer US. https://doi.org/10.1007/978-1-4615-4163-9_26
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