Biocompatible glasses for controlled release technology

Abstract

In order to treat, relief or prevent diseases, new drugs and alternative procedures have been continuously developed. Recently, the introduction of concepts involving controlled release technology brought new perspectives for the development of drug systems. These systems aim to diminish drugs side effects and, at the same time, to increase their efficacy. In this sense, bioactive glasses have been used as new carrier systems to delivery ions, bioactive molecules (including drugs) and even cells. In this chapter, it was covered most of the main characteristics of bioactive glasses that must be take into account during the development of new carrier systems: glass composition, morphology and its interaction with the chosen drug. A relevant discussion about composites consisted of polymer/bioactive glasses was also included along the chapter. Finally, some of the most recent pharmacological breakthroughs using bioactive glasses are reviewed, such as applications in bone regeneration, osteomyelitis and cancer treatment.