CCR7 & lymphotoxin in lymphoma niche

Abstract

The role of microenvironmental interactions in lymphoma growth is increasingly being recognized but still poorly understood. In this issue of Blood, ,Rehm and colleagues used amouse model of aggressive B-cell lymphoma to show that the chemokine receptor CCR7 plays a pivotal role in homing of tumor cells into lymphoma-supporting niches in secondary lymphoid organs, and that lymphotoxin signaling is involved in a tumor-promoting reciprocal interaction between lymphoma cells and fibroblastic reticular cells in these niches.