Leptin, a pleiotropic hormone is produced by adipose tissues and plays a critical role in various biological functions. Leptin mediates its function through interaction with specific receptors. The leptin-receptor interaction modulates activation of a number of signaling pathways, such as JAK-STAT, PI3-Kinase-AKT and MAP kinases. Recently, deregulated leptin-mediated signaling has been shown in many cancers including ovarian cancer. A number of studies have shown a link between obesity and carcinogenesis of different cancers via leptin deregulated signaling pathways. In this review, we highlighted the role of deregulated leptin receptor-mediated signaling in the etiology of ovarian cancer.
CITATION STYLE
Achkar, I. W., Bhat, A. A., Zafar, M., Abbas, M., Khan, O. S., Kuttikrishnan, S., … Uddin, S. (2019). Oncogenic role of dysregulated leptin signaling in the pathogenesis of ovarian cancer. Translational Medicine Communications, 4(1). https://doi.org/10.1186/s41231-018-0031-2
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