A new class of antimycobacterial drugs: the diarylquinolines

Abstract

▴ Andries K, Verhasselt P, Guillemont J, et al . A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science2005;307:223–7 [OpenUrl][1][Abstract/FREE Full Text][2] Over three million people die from tuberculosis (TB) every year, and drug resistance is an increasing problem. This paper reports the development of a promising new anti-TB agent, R207910, a diarylquinoline. It acts as an inhibitor of mycobacterial … [1]: {openurl}?query=rft_id%253Dinfo%253Adoi%252F10.1126%252Fscience.1106753%26rft_id%253Dinfo%253Apmid%252F15591164%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=sci&resid=307/5707/223&atom=%2Fthoraxjnl%2F60%2F6%2F495.atom