Modeling calcium-overload mediated necrosis in drosophila

Abstract

Necrotic cell death (necrosis) occurs in many acute-onset diseases. However, our poor understanding of its mechanism has greatly limited medical interventions. Here we describe two methods to establish necrosis models in Drosophila. Our strategy is to overload calcium by expression of leaky cation channels. © Springer Science and Business Media, LLC 2013.