Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis

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Abstract

The incidence of autoantibodies to glomerular basement membrane (AGBMA) and neutrophil cytoplasmic antigens (ANCA) in the initial sera of 889 consecutive patients with a suspected diagnosis of rapidly progressive glomerulonephritis, was determined by prospective study. Forty-seven (5%) were positive for AGBMA alone, 246 (28%) were positive for ANCA alone, 576 (65%) had neither autoantibodies while 20 (2%) had both. Clinical and pathological data collected from patients with both autoantibodies suggested the coexistence of anti-glomerular basement membrane disease and systemic vasculitis. Together, assays for AGBMA and ANCA are important in the diagnosis and management of rapidly progressive glomerulonephritis and may help its further classification.

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Jayne, D. R. W., Marshall, P. D., Jones, S. J., & Lockwood, C. M. (1990). Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis. Kidney International, 37(3), 965–970. https://doi.org/10.1038/ki.1990.72

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