Socioeconomic status as a risk factor for dementia death: Individual participant meta-analysis of 86 508 men and women from the UK

Abstract

Background: Life-course socioeconomic factors may have a role in dementia aetiology but there is a current paucity of studies. Meta-analyses of individual participant data would considerably strengthen this evidence base. Aims: To examine the association between socioeconomic status in early life and adulthood with later dementia death. Method: Individual participant meta-analysis of 11 prospective cohort studies (1994-2004, n = 86 508). Results: Leaving full-time education at an earlier age was associated with an increased risk of dementia death in women (fully adjusted hazard ratio (HR) for age ≤4 v. age ≥6: HR = 1.76, 95% CI 1.23-2.53) but not men. Occupational social class was not statistically significantly associated with dementia death in men or women. Conclusions: Lower educational attainment in women was associated with an increased risk of dementia-related death independently of common risk behaviours and comorbidities.