Functional Evaluation Model for Lactic Acid Bacteria

Abstract

With the deepening exploration of the relation between the gut microbiota and the host health, the health-promoting effect of lactic acid bacteria has been further analyzed and explored. Numerous studies have shown that in addition to the widely recognized functions like antagonizing pathogenic bacteria, regulating gut microbiota, and improving immunity, lactic acid bacteria may also have a series of special physiological functions such as antioxidant, anti-mutation, biological elimination of toxic and harmful substances, and reduction of cardiovascular diseases. At present, many studies have attempted to develop a mature, accurate, and high-throughput functional evaluation model for the characteristics mentioned above to efficiently screen the strains, obtain probiotic strains with excellent physiological characteristics, and then verify and evaluate its function by in vitro models, cell models, as well as in vivo models. The establishment of these functional evaluation models is beneficial to figure out the health-promoting benefits of lactic acid bacteria and provides a good reference for the strain screening and physiological evaluation of follow-up researchers.