Myometrial wound healing post-cesarean delivery in the MRL/MPJ mouse model of uterine scarring

69Citations
Citations of this article
66Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

There is little known about healing of the uterus after Cesarean delivery (CD). Uterine wound repair was studied by using two strains of mice with different wound healing characteristics: MRL/MpJ+/+ (MRL: "high-healer" phenotype) and C57Bl/6 ("low-healer" phenotype). First, we examined the morphology and histology of the uterine wall repair. We identified wound granulation tissue 3 days post-CD in both strains, albeit less in the MRL strain. Macroscopically, no scar could be identified either in MRL or C57Bl/6 mice on day 60 post-CD. However, histologically, we found significant differences in wound integration, inflammation, and collagen birefringence between the two strains of mice. Using a histological index, we provided evidence for significant differences in mitotic activity in the initial phases of uterine healing among strains. Functional behavior of the uterine scar also was analyzed by using biomechanical parameters such as slope (measure of stiffness), yield point (measure of elasticity), and break point (measure of strength). There were significant differences in stiffness of the scarred myometrium between the two phenotypes. MRL mice displayed a significantly lower yield point compared with C57Bl/6. The break point was reached faster on days 15 and 60 in both C57Bl/6 and MRL strains compared with day 3 post-CD. Our findings indicate that differences in regenerative ability translate in histological , mitotic , and functional differences in biomechanical properties of the scarred myometrium after CD. Copyright © American Society for Investigative Pathology.

Cite

CITATION STYLE

APA

Buhimschi, C. S., Zhao, G., Sora, N., Madri, J. A., & Buhimschi, I. A. (2010). Myometrial wound healing post-cesarean delivery in the MRL/MPJ mouse model of uterine scarring. American Journal of Pathology, 177(1), 197–207. https://doi.org/10.2353/ajpath.2010.091209

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free