0949 The Relationships between Circadian Rhythm, Sleep Quality, Fatigue, and Depressive Symptoms Among Adults with Multiple Sclerosis (MS)

Abstract

Conclusion: In our cohort we found that Parkinson patients had more severe sleep misperception than controls; however they were not different with respect to other objective parameters or their degree of sleepiness. This suggests their misperception may be related to an altered experience of sleep continuity. Further studies are needed to investigate sleep misperception in Parkinson's patients. Support (If Any): N/A Introduction: The objective was to investigate the impact of sleep-wake disturbances (SWD) on cognitive function and quality of life measures in the post-acute phase of stroke. Sex differences were also investigated. Methods: Adult stroke (n=58) patients were assessed for SWD via overnight polysomnography. The mean age was 51 ± 2 years and mean latency from injury was 116 ± 13 days. Sleep measures included total sleep time (TST), sleep and REM latency, percent time in sleep stages, apnea/hypopnea index (AHI), wake after sleep onset (WASO), and arousal index. The primary outcome measures were: Montreal Cognitive Assessment (MoCA), Neuro-QoL and Mayo Portland Adaptability Inventory (MPAI). Results: Women had lower AHI (F(1,51)=12.236, p <3% of TST in 67% of patients. Analysis of NeuroQOL measures indicated the following: Longer latencies to sleep were associated with increases in subjective stigma and depression (p