Effect of Recombinant Canine Granulocyte Colony‐stimulating Factor on Peripheral Blood Neutrophil Counts in Normal Cats

25Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Recombinant canine granulocyte colony‐stimulating factor (rcC‐CSF) was administered subcutaneously at a dosage of 5 μg/kg/day to five healthy, young adult cats for 42 days. Mean neutrophil counts ± standard deviation increased significantly (P > 0.001) from 10,966/μL ± 2324 to 30,688/μL ± 5296 within 24 hours after administration of the first dosage of rcG‐CSF. Mean neutrophil counts reached 52,978/μL ±11,207 on day 6, representing a second significant increase (P > 0.01) over the previous 5 days. Mean neutrophil counts continued to increase, reaching 66,994/μL ± 12,419 on day 14, then remaining within a range of 66,994 to 87,839/μL throughout the remainder of the study. The maximum mean neutrophil count was 87,839/μL ± 8,695 on day 42. Neutrophil counts remained high until the administration of recombinant canine granulocyte colony‐stimulating factor was discontinued 42 days after initiation of therapy. Once the rcG‐CSF administration was discontinued, neutrophil counts returned to pretreatment values within 5 days. There were no significant changes in numbers of any of the other cell lines. There was no clinically significant toxicosis associated with the administration of rcGCSF. © 1993 American College of Veterinary Internal Medicine

References Powered by Scopus

Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium

872Citations
N/AReaders
Get full text

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution after High-Dose Chemotherapy and Autologous Bone Marrow Transplantation

659Citations
N/AReaders
Get full text

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Chemotherapy-Induced Myelosuppression

611Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Supporting the Veterinary Cancer Patient on Chemotherapy: Neutropenia and Gastrointestinal Toxicity

41Citations
N/AReaders
Get full text

Production of granulocyte colony - stimulating factor and granulocyte-macrophage colony - stimulating factor by carcinomas in a dog and a cat with paraneoplastic leukocytosis

32Citations
N/AReaders
Get full text

Biological response modifiers: Interferons, interleukins, recombinant products, liposomal products

27Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Obradovich, J. E., Ogilvie, G. K., Stadler‐Morris, S., Schmidt, B. R., Cooper, M. F., & Boone, T. C. (1993). Effect of Recombinant Canine Granulocyte Colony‐stimulating Factor on Peripheral Blood Neutrophil Counts in Normal Cats. Journal of Veterinary Internal Medicine, 7(2), 65–67. https://doi.org/10.1111/j.1939-1676.1993.tb03171.x

Readers over time

‘11‘15‘16‘17‘18‘2200.751.52.253

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

60%

Researcher 2

40%

Readers' Discipline

Tooltip

Medicine and Dentistry 3

50%

Agricultural and Biological Sciences 1

17%

Biochemistry, Genetics and Molecular Bi... 1

17%

Veterinary Science and Veterinary Medic... 1

17%

Save time finding and organizing research with Mendeley

Sign up for free
0