Cryo-EM is a method for reconstructing 3D structure of proteins without crystallization. The Expectation-Maximization (EM) algorithm is used in the alignment step of Cryo-EM reconstructions. The EM step is often a serious computational bottleneck for 3D reconstructions. This paper proposes a computationally adaptive version of the EM algorithm that speeds up the algorithm by a factor of 20 - 30. Experiments with noisy real-world data are included to show that the algorithm achieves this speedup without any significant loss of accuracy. Such speed ups are significant, allowing the reconstruction to converge in cpu-days rather than cpu-months. © 2008 Springer Berlin Heidelberg.
CITATION STYLE
Tagare, H. D., Sigworth, F., & Barthel, A. (2008). Fast, adaptive expectation-maximization alignment for Cryo-EM. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 5242 LNCS, pp. 855–862). Springer Verlag. https://doi.org/10.1007/978-3-540-85990-1_103
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