Prenatal exposure to organochlorine pesticides and cryptorchidism

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Abstract

Fetuses and children are more susceptible to the effects of environmental toxins. The objective of this article is to determine the levels of organochlorine pesticides (HCB, ß-HCH, pp'DDT, op'DDT and pp'DDE) in the serum lipids of mothers of newborns with cryptorchidism and compare the levels to a control group of mothers of newborns with descended testicles. The cases were composed of newborns with cryptorchidism (n=41), and the controls (n=41) newborns with descended testicles. Blood samples from both groups of mothers were used to determine the organochlorine pesticide levels. Cryptorchidism was diagnosed at birth by a neonatologist. The results showed that the organochlorine pesticide residues were found in the serum lipids of both groups of mothers. The median serum lipid levels (mgkg-1 lipid- based) were statistically higher for the metabolites pp'DDT (0.464 vs. 0.269) and ß-HCH (0.263 vs. 0.192) in the cryptorchidism group compared to the control group (p<0.01). It could be concluded that the levels of the metabolites pṕDDT and ß- HCH are higher among mothers of newborns with cryptorchidism. It is possible that substances with anti-androgenic effects could produce endocrine disruption, such as cryptorchidism, during fetal development.

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Montes, L. P. B., Waliszewski, S., Hernández-Valero, M., Sanín-Aguirre, L., Infanzón-Ruiz, R. M., & Jañas, A. G. (2010). Prenatal exposure to organochlorine pesticides and cryptorchidism. Ciencia e Saude Coletiva, 15(SUPPL. 1), 1169–1174. https://doi.org/10.1590/s1413-81232010000700025

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