Epidural morphine reduces halothane MAC in the dog

Abstract

Morphine, 0.1 mg · kg-1 was administered epidurally on two different occasions to ten dogs to determine the effect of two different volumes of saline dilution, 0.13 and 0.26 ml · kg-1, on the minimum alveolar concentration (MAC) of halothane as determined by subcutaneous electrical current applied to the fore and hind limbs in a random order. Following MAC determination with halothane alone, epidural morphine was administered and MAC was redetermined. Epidural morphine significantly reduced, P < 0.001, the MAC of halothane for fore and hind legs in both volume groups; from 1.04 ± 0.038 to 0.68 ± 0.034 and 0.60 ± 0.017 for fore and hind limbs, respectively, in the large volume group, and from 0.96 ± 0.038 to 0.66 ± 0.088 and 0.60 ± 0.030 for fore and hind limbs, respectively, in the small volume group. The reduction in MAC was significantly greater, P < 0.025, in the hind limb. This study indicates that epidural morphine reduces the halothane requirements in the dog in a segmental manner. The volume of administration was not shown to be critical. Epidural morphine, 0.1 mg · kg-1, diluted in 0.13 to 0.26 ml · kg-1 saline produces significant analgesia in the dog as far forward as the fore limb and will reduce the halothane requirement to permit surgery. © 1989 Canadian Anesthesiologists.