In this chapter we provide an exhaustive overview of the binding modes of bile acid (BA) and non-BA ligands to the nuclear farnesoid X receptor (FXR) and the G-protein bile acid receptor 1 (GPBAR1). These two receptors play a key role in many diseases related to lipid and glucose disorders, thus representing promising pharmacological targets. We pay particular attention to the chemical and structural features of the ligand-receptor interaction, providing guidelines to achieve ligands endowed with selective or dual activity towards the receptor and paving the way to future drug design studies.
CITATION STYLE
Di Leva, F. S., Di Marino, D., & Limongelli, V. (2019). Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators. In Handbook of Experimental Pharmacology (Vol. 256, pp. 111–136). Springer New York LLC. https://doi.org/10.1007/164_2019_234
Mendeley helps you to discover research relevant for your work.