Electric impulses were found to cause transient permeability changes in the membranes of vesicles storing biogenic amines. Release of catecholamines induced by electric fields (of the order of 20 kV/cm and decaying exponentially with a decay time of about 150 μsec) was studied, using the chromaffin granules of bovine adrenomedullary cells as a vesicular model system. Far-UV-absorption spectroscopy was applied to determine the amount of catecholamines released from suspended vesicles. A polarization mechanism is suggested for the induction of short-lived permeability changes caused by electric fields. Such transient changes in permeability may possibly represent a part of the sequence of events leading to stimulated neurohumoral secretion. © 1972 Springer-Verlag New York Inc.
CITATION STYLE
Neumann, E., & Rosenheck, K. (1972). Permeability changes induced by electric impulses in vesicular membranes. The Journal of Membrane Biology, 10(1), 279–290. https://doi.org/10.1007/BF01867861
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