Asymmetric Dimethylation on Arginine (ADMA) of Histones in Development, Differentiation and Disease

Abstract

Among myriads of histone modifications known today, asymmetric dimethylation of arginines (ADMA) have been found to have important implications in transcriptional regulation of gene expression. These modifications influence organismal development, regulate cellular differentiation of multiple lineages and modulate pathogenesis of various disease forms such as cancer, metabolic disorders and drug addiction. In this chapter, we discuss roles of ADMA of histones mediated by different type I PRMTs in above mentioned physiological contexts and shed light on prospective therapeutic developments.