Hydroxyethyl starch or gelatin impairs, but Ringer's acetate enhances, coagulation capacity dose dependently after cardiac surgery

Abstract

Forty-five patients received three relatively rapid boluses (each 7 ml/kg) of either 6% HES (130/0.4) (n = 15), 4% gelatin (n = 15), or Ringer's acetate (n = 15) in a randomized, blinded fashion after elective on-pump cardiac surgery to maintain optimal intravascular volume. The study solution was continued as an infusion (7 ml/kg) for the following 12 hours. The total cumulative dose of the study solution was 28 ml/kg. If signs of hypovolemia were observed, Ringer's acetate was given. Blood coagulation was assessed by thromboelastometry (ROTEM).CC - HS-INJCC - HS-HANDSRCHUD - 03/03/2014CD - 08/12/2011