Epilepsy is an excellent indication for gene therapy due to a significant unmet need, which is the high percentage of patients with symptoms that remain inadequately relieved by the current available treatments. This chapter provides an up-to-date review on the preclinical studies assessing the potential of gene therapy for epilepsy. We also provide here a set of procedures that can be used as a starting point to evaluate potential therapeutic candidates for epilepsy gene therapy. The techniques described here include adeno-associated viral vector production, genomic titering of the vector, stereotaxic neurosurgery for intracerebral vector administration, and the kainic acid seizure model.
CITATION STYLE
During, M. J. (2015). Gene therapy for epilepsies. Neuromethods, 98, 229–264. https://doi.org/10.1007/978-1-4939-2306-9_10
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