The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for de novo cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo data proved the ability of the tested bioink to form a cartilage within five to six weeks after the subcutaneous scaffold implantation. Certain areas of cartilage formation were detected as early as in one week. The resulting cartilage tissue had a distinctive structure with groups of isogenic cells as well as a high content of glycosaminoglycans and type II collagen.
CITATION STYLE
Beketov, E. E., Isaeva, E. V., Yakovleva, N. D., Demyashkin, G. A., Arguchinskaya, N. V., Kisel, A. A., … Kaprin, A. D. (2021). Bioprinting of cartilage with bioink based on high-concentration collagen and chondrocytes. International Journal of Molecular Sciences, 22(21). https://doi.org/10.3390/ijms222111351
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