Study on the chemical constituents of Premna integrifolia L.

Abstract

Phytochemical study on the plant Premna integrifolia L. led to the isolation of twelve compounds. In which, a new acylated iridoid glycoside, 6-O-(3″-O-acetyl-2″-O-trans-p-coumaroyl)-α-L- rhamnopyranosylcatalpol (premnacorymboside A) (1), was isolated from the flowers along with 10-O-trans-p-methoxycinnamoylcatalpol (3) and verbascoside. From the leaves, a new iridoid glycoside, 6-O-(3″-O-trans-p-coumaroyl)-α-L- rhamnopyranosylcatalpol (premnacorymboside B) (2), together with 10-O-trans-p-methoxycinnamoylcatalpol (3), scutellarioside II (4), premnaodoroside A (5), 1-O-trans-p-coumaroyl-α-L-rhamnopyranoside, hexyl glucoside, 4-hydroxy-2-methoxybenzaldehyde, and 4-hydroxybenzaldehyde were obtained. The new compound premnacorymboside A (1) and scutellarioside II (4), were also isolated from the stem bark along with quercetin 3-rutinoside and leonuriside A. The structure determinations were based on physical and spectroscopic evidence.