Neural firing patterns are more schematic and less sensitive to changes in background visual scenes in the subiculum than in the hippocampus

Abstract

Literature suggests that the hippocampus is central to processing visual scenes to remember contextual information, but the roles of its downstream structure, subiculum, remain unknown. Here, single units were recorded simultaneously in the dorsal CA1 and subiculum while male rats made spatial choices using visual scenes as cues in a T-maze. The firing fields of subicular neurons were schematically organized following the task structure, largely divided into pre-choice and post-choice epochs, whereas those of CA1 cells were more punctate and bound to specific locations. When the rats were tested with highly familiar scenes, neurons in the CA1 and subiculum were indistinguishable in coding the task-related information (e.g., scene, choice) through rate remapping. However, when the familiar scenes were blurred parametrically, the neurons in the CA1 responded sensitively to the novelty in task demand and changed its representations parametrically following the physical changes of the stimuli, whereas these functional characteristics were absent in the subiculum. These resultssuggestthattheuniquefunctionofthehippocampusistoacquirecontextualrepresentations in association with discrete positions in space, especially when facing new and ambiguous scenes, whereas the subiculum may translate the position-bound visual contextual information of the hippocampus into schematic codes once learning is established.