Receptors for Targeting Growth Factors for Treatment of Cancers

Abstract

Growth factor receptors (GFR)Growth factor receptors (GFR) are expressed on cell membranes or in the cytoplasm and play a major role in cell growth, survival, angiogenesis, and metastasis. Tumor growth and cell survival are composed of dodging apoptotic signals in cancer cells. The growth of cells is further supported by angiogenesis and metastasis to distant organs. Elevated expression of growth factor receptors contributes to the development of drug resistance. Therefore, therapeutics to target GFRs is a potentially attractive molecular approach to treat cancer more effectively. In this review, we have discussed the contribution of growth factor receptors to cancer development and thereby their subsequent molecular targets for novel drugs developed leading to inhibition of growth factor receptor-mediated pathways.