A comparative study on the antioxidant activity of two polysaccharides from Ganoderma lucidum

Abstract

Two polysaccharides from Ganoderma lucidum (GLP1 from fermentation broth and GLP2 from fruiting body) were obtained and investigated for their in vitro antioxidant properties. The two polysaccharides showed strong antioxidant activities in a dose-dependent manner. At 5.0 mg/mL, the reducing power and the scavenging rate on DPPH radical and hydroxyl radical of GLP1 were 1.25, 50 and 80%, while that of GLP2 were 1.46, 85, and 78%, respectively. GLP1 and GLP2 also showed strong protective effects on yeast cells from UV and H2O2 damage. At 20 mg/mL, the protective effects on yeast cells from UV and H2O2 of GLP1 were 57 and 49%, and that of GLP2 were 84 and 79%, respectively. Thus, both GLP1 and GLP2 could be considered as antioxidants for food and pharmaceutical industries.