Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with increased oxidative stress (OS) and mitochondrial alterations. Fish oil consumption has neuroprotective, antioxidant and anti-inflammatory effects in patients with relapsing-re-current MS (RR-MS). Objective: To evaluate changes in the hydrolytic activity of ATP synthase and mitochondrial membrane fluidity in patients with RR-MS who receive fish oil or olive oil as a dietary supplement. Methods: Clinical, controlled, randomized, double-blind trial. Patients consumed fish oil or olive oil for one year. The hydrolytic activity of ATPase and the fluidity of the mitochondrial membrane of platelets were quantified. Results: In patients with RR-MS, a decrease in the fluidity of mitochondrial membranes and an increase in the hydrolytic activity of ATP synthase was observed in comparison with healthy controls. After 6 or 9 months of treatment with fish oil or olive oil, respectively, these values were normalized. Conclusion: The consumption of fish oil and olive oil increases the fluidity of the mitochondrial membranes and decreases the catabolic activity of ATP synthase in platelets from patients with RR-MS.
CITATION STYLE
Torres-Sánchez, E. D., Pacheco-Moisés, F. P., Macias-Islas, M. A., Morales-Sánchez, E. W., Ramírez-Ramírez, V., Celis De La Rosa, A. J., … Ortiz, G. G. (2018). Efecto del aceite de pescado en la actividad hidrolítica de la ATPasa y en la fluidez de la membrana mitocondrial en pacientes con esclerosis múltiple remitente-recurrente tratados con interferón beta 1-b. Nutricion Hospitalaria, 35(1), 162–168. https://doi.org/10.20960/nh.1084
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