Lack of oncostatin M receptor β leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype

Abstract

Background: OSM, a member of IL-6 family of cytokines, is involved in many inflammatory diseases. Results: OSMRβ-/- mice exhibited phenotypic changes in ATMs to M1, increased proinflammatory cytokines in the adipose tissue, and systemic insulin resistance. Conclusion: OSMRβ-/- mice exhibited adipose tissue inflammation and insulin resistance preceding obesity. Significance: OSMRβ-/- mice constitute a unique mouse model of metabolic disorders. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.