Background: The number of reports on sarcoidosis complicated by hypersensitivity pneumonitis (HP) is limited, and most describe cases complicated by chronic bird-related HP. Here, we present for the first time a case with Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related HP. Case presentation: A 62-year-old man with a past medical history of sarcoidosis was admitted to our department, and chest computed tomography showed diffuse ground-glass opacities, which appeared as he rapidly increased the number of pigeons he kept for a competition. Random transbronchial lung biopsy revealed well-formed non-caseating epithelioid granulomas, which contained positively stained substances on immunohistochemistry using the PAB antibody, a specific monoclonal antibody against P. acnes lipoteichoic acid. Poorly formed non-caseating granulomas without positively stained substances were also detected. Conclusion: We describe the successful identification of this exceptionally rare case of sarcoidosis complicated by acute bird-related HP in which two morphologically and immunohistologically different types of granulomas were present in the same lung.
CITATION STYLE
Sawahata, M., Sakamoto, N., Yamasawa, H., Iijima, Y., Kawata, H., Yamaguchi, T., … Hagiwara, K. (2020). Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related hypersensitivity pneumonitis. BMC Pulmonary Medicine, 20(1). https://doi.org/10.1186/s12890-020-01327-z
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