Abstract
I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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CITATION STYLE
Popat, A., Ross, B. P., Liu, J., Jambhrunkar, S., Kleitz, F., & Qiao, S. Z. (2012). Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres. Angewandte Chemie - International Edition, 51(50), 12486–12489. https://doi.org/10.1002/anie.201206416
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