Hippo inactivation feeds tumor-initiating cells

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The Hippo pathway has emerged as a well-conserved kinase cascade controlling cell proliferation and survival and has recently gained much attention for its key activity as a tumor suppressor. In a study published in Cell, Cordenonsi and colleagues link TAZ, a downstream effector of the Hippo pathway, to attributes of putative breast cancer stem cells, epithelial-to-mesenchymal transition and cell polarity. © 2012 BioMed Central Ltd.




Duss, S., Britschgi, A., & Bentires-Alj, M. (2012). Hippo inactivation feeds tumor-initiating cells. Breast Cancer Research, 14(4). https://doi.org/10.1186/bcr3190

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