Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal transduction, mitosis, lipid homeostasis, and directed migration, among others. Less well-appreciated are the roles various forms of endocytosis plays in regulating αβ and, especially, γδ T cell functions, such as T cell receptor signaling, antigen discovery by trogocytosis, and activated cell growth. Herein we examine the contribution of both clathrin-mediated and clathrin-independent mechanisms of endocytosis to T cell biology. [MediaObject not available: see fulltext.]
CITATION STYLE
Charpentier, J. C., & King, P. D. (2021, December 1). Mechanisms and functions of endocytosis in T cells. Cell Communication and Signaling. BioMed Central Ltd. https://doi.org/10.1186/s12964-021-00766-3
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