1131 CHARACTERIZATION OF OBJECTIVE AND SUBJECTIVE SLEEP IN PATIENTS RECEIVING BUPRENORPHINE MAINTENANCE THERAPY FOR OPIOID USE DISORDER

Abstract

Introduction: Sleep disturbances associated with opioid use disorder (OUD) are well recognized. Characterization of sleep abnormalities in individuals on buprenorphine maintenance therapy, a partial mu-opioid agonist used for the treatment of OUD, is limited. Our aim was to characterize and compare subjective and objective sleep measurements in this population. Methods: We assessed sleep as part of a longitudinal naturalistic study of individuals with OUD in opioid maintenance therapy. Participants (N = 26) receiving outpatient-based buprenorphine maintenance therapy completed daily electronic sleep diaries and ambulatory EEG monitoring for one week. Participants also self-reported sleep quality and drug use on electronic diaries. Results: The majority of patients were male (77%), middle-aged (46 ± 11 years), and African American (77%). 92% of participants were cigarette smokers and 77% of participants reported using other substances. Ambulatory EEG monitoring demonstrated poor sleep in terms of total sleep time (262 ± 73 min), sleep efficiency (.73 ± .11), wake after sleep onset (59 ± 38 min), and sleep latency (27 ± 19 min). However, participants reported relatively high sleep quality (7.1/10 ± 1.6). Patients reported significantly greater total sleep time (370 ± 86 min), sleep efficiency (.92 ± .05), and less wake after sleep onset (14 ± 16 min) (p's