Long-range diffusion of hyperpolarized3He in rats

Abstract

Based on a stimulated-echo technique, a method to construct an apparent diffusion coefficient (ADC) map of hyperpolarized 3He in a long-range diffusion scale is presented with a phase- cycle alternative to remove all unwanted echoes. The approach was successfully applied to determine in vivo diffusion constants in rat lungs. The ADC values in healthy rats show a good agreement with reported values for diffusion times of - These long diffusivity measurements may be sensitive to detect emphysema progression or tissue remodeling and thus have enormous potential for the diagnosis and tracking of disease progression and for drug evaluation. © 2008 Wiley-Liss, Inc.