Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses

Abstract

Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs. © 2007 Springer Science+Business Media B.V.