Pyrrolo[1,2-a]quinazolines. Synthesis and biological properties

Abstract

Pyrrolo[1,2-a]quinazolines have raised some interest as bioactive scaffolds but their synthetic strategies based mainly on the anthranilic acid route have been rather limited. The last two decades have brought new approaches to the synthesis of pyrrolo[1,2-a]quinazoline framework and thus their potential could be valued in the obtaining of new lead compounds from the important class of quinazolines. Herein we present the synthetic strategies towards compounds containing the pyrrolo[1,2-a]quinazoline scaffold and their biological properties.