A quantitative structure-activity relationship (QSAR) study of peptide drugs based on a new of amino acids

6Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

The quantitative structure-activity relationship (QSAR) approach is used for finding the relationships between molecular structures and the activity of peptide drugs. In this work, the stepwise multiple regression method was employed to select the optimal subset of that have significant contributions to the drug activity of 21 oxytocin analogues, 48 bitter tasting threshold activities and 58 angiotensin-converting enzyme inhibitors. A new set of , SVWGM, was used for the prediction of the activity of the peptide drugs and then were used to build a model by the partial least squares method, The stability and generalization ability of the model was strictly analyzed by both internal and external validations, by cross-validation and external validation correlations.

Cite

CITATION STYLE

APA

Tong, J. B., Chang, J., Liu, S. L., & Bai, M. (2015). A quantitative structure-activity relationship (QSAR) study of peptide drugs based on a new of amino acids. Journal of the Serbian Chemical Society, 80(3), 343–353. https://doi.org/10.2298/JSC140604069T

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free