Sequential molecular conjugation using thiophene S,S-dioxides bearing a clickable functional group

Abstract

Electron-deficient thiophene dioxides have been found to react rapidly with a bicyclo[6.1.0]non-4-yne derivative to afford benzocyclooctenes in excellent yields. Thiophene dioxides bearing a clickable functional group served as efficient bisreactive platform molecules that enabled sequential molecular conjugation in a simple operation.