Facile synthesis of novel hybrid POSS biomolecules: Via "click" reactions

Abstract

A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield (82-90%). The X-ray crystal structure revealed intra- and intermolecular hydrogen bonding between the amide groups of the arms. Hybrid biomaterials were synthesised in nearly quantitative yields via a click reaction with (i) azido-N-Fmoc-norleucine and (ii) 3′-azido-3′-deoxythymidine.