Respuesta inflamatoria postoperatoria en pacientes con cáncer gástrico resecado

Abstract

Introduction: The removal of the stomach causes an acute inflammatory respons e. In some cases this response is exaggerated due to complications. The main purpose of this study was to describe the expected inflammatory response to gastrectomy. Methods: This is a prospective analysis of consecutive patients submitted to gastrectomy for gastric cancer. For analytical purposes, the cohort was divided in complicated and uncomplicated patients. Uncomplicated patients were further divided in total gastrectomy and partial gastrectomy. The main outcome measure was to compare the inflammatory response of uncomplicated and complicated patients. The secondary outcome measure was to compare the inflammatory response of uncomplicated patients submitted to total and partial gastrectomy along the timeline. Results: Preoperative values were similar between groups. At 24 h after gastrectomy, complicated patients showed significantly higher values for D-dimer, CRP and WBC. Further analysis comparing uncomplicated patients showed normal preoperative values and a mild elevation of inflammatory parameters which was similar in both groups of patients. Conclusions: The expected systemic inflammatory response to partial or total gastrectomy was mild. Elevations of inflammatory values were shown early by complicated patients, constituting reliable parameters to identify postoperative inflammatory complications.