Investigation of aberrant translational control of c-myc in cell lines derived from patients with multiple myeloma

7Citations
Citations of this article
3Readers
Mendeley users who have this article in their library.
Get full text

Abstract

In cell lines derived from patients with multiple myeloma (MM) we have found an elevation in the amount of the c-myc protein which is not accompanied by an increase in the level of mRNA or a change in the half-life of the protein. There is a 3.4 fold enhancement in the degree of association of the c-myc message with polysomes. This is not accompanied by an alteration in polysome size or a change in the transit time of the c-myc mRNA on the polysomes thus suggesting that there is an increase in the degree of mobilisation of the c-myc message. Sequencing of the c-myc 5'UTR has revealed the presence of a mutation in all the MM cell lines studied and we demonstrate that this mutation causes altered binding of cellular proteins to this RNA species.

Cite

CITATION STYLE

APA

Willis, A. E., Paulin, F. E. M., West, M. J., & Whitney, R. L. (1997). Investigation of aberrant translational control of c-myc in cell lines derived from patients with multiple myeloma. In Current Topics in Microbiology and Immunology (Vol. 224, pp. 269–278). Springer Verlag. https://doi.org/10.1007/978-3-642-60801-8_28

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free