Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). In this cross-sectional study, we included 28 women with RIF, 29 healthy women who had conceived by in vitro fertilization (IVF), and 30 women with a 1-cycle failure of IVF as controls. Human serum nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1/SIRT2L1) levels were detected using a commercial colorimetric kit. Recurrent implantation failure patients have higher sirtuin 1 levels than non-pregnant women and healthy pregnant women, but this difference did not reach statistical significance due to the low number of patients in our study. These higher sirtuin 1 levels may result from the inflammation imbalance of RIF patients. The only statistically significant correlation found was between age and sirtuin (r = 0.277, p = 0.009).
CITATION STYLE
Engin-Ustun, Y., Ozgu-Erdinc, A. S., Caglayan, E. K., Gulerman, C., Sarikaya, E., Aktulay, A., … Yilmaz, N. (2017). Níveis de sirtuína 1 em falhas recorrentes de implantação. Revista Brasileira de Ginecologia e Obstetricia, 39(10), 541–544. https://doi.org/10.1055/s-0037-1606349
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