The efficacy of Nigella sativa oil in the prophylaxis and treatment of upper respiratory tract infections in children

Abstract

The aim of this study was to investigate the efficacy of Nigella sativa oil (NSO) in pediatric Upper Respiratory Tract Infections (URTI). 230 pediatric URTI patients who were consecutively admitted to Family Medicine Outpatient Clinic between 05/12/2022 and 05/09/2023 whose parents agreed to participate were enrolled. Examinations were completed with 110 cases who were orally consuming standardized NSO exclusively, while 120 controls used no phytotherapeutics. Relationships of categorical variables were analysed by Chi-square. Group comparisons of continuous variables were performed with either t-test or Mann-Whitney U test, depending on the normality of distribution. Time-dependent differences in continuous variables between groups were analyzed by rANOVA. Generally accepted significance was p < 0.05. There were 230 cases, 108 boys and 122 girls. The mean age was 10.76 ± 3.75 years. The case and control groups were similar (p > 0.05) in terms of age and gender. At first follow-up, severity scores (p < 0.001) and prevalence of antibiotic use (p < 0.001) were significantly lower in cases compared to controls. Prevalence of visits with URTI and severity scores were significantly reduced at the 2nd follow-up (both p < 0.001). Time-dependent changes in all outcome measures were significantly in favor of cases (p < 0.001 for all). This study showed that severity score, prevalence of antibiotic use and visits with URTI decreased with oral NSO use. This study supports the existing evidence that natural products are promising alternative treatments with their safety and versatility and hopefully may promote further research on appropriate dosage, safety and efficacy of these drugs for evidence based and safe complementary treatments.