A practical and environmentally friendly organocatalytic one-pot strategy designed to furnish the hetero-Diels-Alder products was shown to be effective in the preparation of disubstituted tetrahydropyranones in a highly selective manner. (S)-1-(2-pyrrolidinylmethyl)pyrrolidine catalyzed an asymmetric assembly reaction involving a hetero-Diels-Alder reaction between alkylidene- and arylidene-acetones generated in situ from Wittig reactions with diethyl ketomalonate to furnish the substituted tetrahydropyranones in moderate to very good yields with moderate enantioselectivity.
CITATION STYLE
Ramachary, D. B., Mondal, R., & Jain, S. (2015). Direct organocatalytic Wittig/Hetero-Diels-Alder reactions in one-pot: Synthesis of highly-substituted tetrahydropyranones. Arkivoc, 2016(2), 98–115. https://doi.org/10.3998/ark.5550190.p009.252
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