Editorial overview

7Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The objective of this issue is to review the genetic bases and immunogenetic variations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), with particular emphasis on major histocompatibility complex class I and II molecules, the polymorphisms in the intercellular adhesion molecule-1 gene, tumor necrosis factor genes, alpha-1-antitrypsin (α1AT) and Fcγ receptor (FcγR) genes. Although the aetiologies of the various AAV are unknown, the available genetic epidemiological data support the importance of genetic factors in susceptibility to these diseases. Moreover, there is considerable reason to believe that immunologic mechanisms contribute to the pathogenesis of AAV. The data presented here indicate that, in addition to immunospecific genes, such as HLA alleles, genes determining the level of the immune response (i.e. cytokines, adhesion molecules, protease inhibitors, FcγR) may contribute to AAV.

Cited by Powered by Scopus

Pathogenesis of diseases associated with antineutrophil cytoplasm autoantibodies

59Citations
N/AReaders
Get full text

Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese

48Citations
N/AReaders
Get full text

The association of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides

46Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Csernok, E., Trabandt, A., & Gross, W. L. (1997). Editorial overview. Experimental and Clinical Immunogenetics. https://doi.org/10.2190/ywck-3ly0-putj-h0rx

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 13

54%

Researcher 5

21%

Professor / Associate Prof. 3

13%

Lecturer / Post doc 3

13%

Readers' Discipline

Tooltip

Social Sciences 8

44%

Business, Management and Accounting 4

22%

Computer Science 3

17%

Engineering 3

17%

Save time finding and organizing research with Mendeley

Sign up for free