Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study

Abstract

Menopausal transition is associated with increased cardiovascular risks. Available data on the effect of earlier climacterium on these risks are limited. Objective: To compare cardiovascular risk-associated parameters at the ages of 14, 31, and 46 in relation to climacteric status at the age of 46. Design, Setting, and Participants: A prospective cohort study including 2685 women from the Northern Finland Birth Cohort 1966. Main Outcome Measures: Follicle-stimulating hormone, bodymass index (BMI), waist circumference, waist-to-hip ratio (WHR), blood pressure (BP), body composition, cholesterol levels, testosterone (T) levels, free androgen index (FAI), high-sensitivity C-reactive protein (hs-CRP), and liver enzymes.