The unquenched reactivity of strong Lewis acids in the presence of Lewis bases in solution, the so-called frustrated Lewis pairs (FLP), has led to the discovery of the metal-free activations, whereas the FLP-mediated hydrogen activation is the most prominent. So far, the metal-free hydrogenation is the most studied application of FLP chemistry and highly efficient methodologies for a number of unsaturated substrates have been developed. This chapter starts with a brief introduction to frustrated Lewis pair chemistry. The second part focuses on the synthetic challenges of chiral borane-derived Lewis acids for asymmetric transformations. The last part gives a state-of-the-art summary of asymmetric transformations using chiral FLPs.
CITATION STYLE
Paradies, J. (2018). Chiral Borane-Based Lewis Acids for Metal Free Hydrogenations. In Topics in Organometallic Chemistry (Vol. 62, pp. 193–216). Springer Verlag. https://doi.org/10.1007/3418_2016_173
Mendeley helps you to discover research relevant for your work.