Clinical research into mutations of the RPGR gene showed that lack of either the RCC1-like domain of the ORF15 causes X-linked retinitis pigmentosa. Thus, the ORF15 and RCC1-like domain play a crucial role in the human retina. Further studies on the role of the RCC1-like domain in the visual Cascade and additional findings of related proteins in the retina or even other organs, will give us a more precise understanding of this protein.
CITATION STYLE
Jin, Z. B., Hayakawa, M., Murakami, A., & Nao-I, N. (2005). RCC1-like domain and ORF15: Essentials in RPGR gene. In Advances in Experimental Medicine and Biology (Vol. 572, pp. 29–33). https://doi.org/10.1007/0-387-32442-9_5
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