In Vivo Murine Models of Brain Metastasis

Abstract

Metastases are the most common tumor type to affect the adult central nervous system. In vivo modeling of brain metastases provides insight into the mechanisms of metastatic development as well as a clinically relevant therapeutic screening platform. Here we describe the development of a novel mouse model of brain metastasis from a primary lung cancer utilizing primary patient samples. These models provide an accurate representation of different stages of the clinical progression of the disease.