BACKGROUND AND PURPOSE: MR imaging studies have demonstrated that magnetic susceptibility in multiple sclerosis lesions is dependent on lesion age. The objective of this study was to use quantitative susceptibility mapping to determine whether lesions with a hyperintense rim, indicative of iron-laden inflammatory cells (rim+), follow a unique time-dependent trajectory of susceptibility change compared with those without (rim-). MATERIALS AND METHODS: We studied patients with MS with at least 1 new gadolinium-enhancing lesion and at least 3 longitudinal quantitative susceptibility mapping scans obtained between 1.1 and 6.1 years. Lesions were classified as rimfiif a hyperintense rim appeared on quantitative susceptibility mapping at any time. A multilevel growth curve model compared longitudinal susceptibility among rim+ and rim-lesions. RESULTS: Thirty-two new gadolinium-enhancing lesions from 19 patients with MS were included, and 16 lesions (50%) were identified as rim. Quantitative susceptibility mapping rimfilesions were larger than rimfilesions with gadolinium enhancement (P
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Zhang, X. S., Nguyen, T. D., Ruá, S. M. H., Kaunzner, U. W., Pandya, S., Kovanlikaya, I., … Gauthier, S. A. (2019). Quantitative susceptibility mapping of time-dependent susceptibility changes in multiple sclerosis lesions. American Journal of Neuroradiology, 40(6), 987–993. https://doi.org/10.3174/ajnr.A6071
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