The diversity of membrane-initiated progesterone actions has made characterization and establishment of its biological importance a complicated endeavor. A new study by Zuo and colleagues shows that progesterone via endogenous membrane progesterone receptor-α acts as a negative regulator of proliferation and epithelial to mesenchymal transition in a breast cancer cell line. These progesterone-mediated actions appear to be regulated through epidermal growth factor receptor and phosphatidylinositol 3-kinase signaling localized in caveolae. Moreover, the study shows expression of membrane progesterone receptor-α in benign and malignant breast cancer tissues. These data bring forth novel concepts with regard to progesterone actions in the breast; however, further work is warranted to fully characterize the physiologic actions of extra-nuclear progesterone signaling in the breast. © 2010 BioMed Central Ltd.
CITATION STYLE
Sen, A., & Hammes, S. R. (2010, April 16). Just when you thought it was safe to go into the membrane: The growing complexities of extra-nuclear progesterone signaling. Breast Cancer Research. https://doi.org/10.1186/bcr2580
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